Experimental study on acute heat injury in lung induced by whole body hyperthermia

Abstract

Acute heat injury in lung during whole body hyperthermia was studied in 54 mongol dogs, especially in regard with Extra Vascular Lung Water (EVLW).
The following results were obtained.
1) Lung edema was observed as a result of severe acute heat injury during whole body hyperthermia. The mesurement of EVLW during whole dody hyperthermia was the most useful parameter for quantitative evalution and early diagnosis of lung edema.
2) Increased permeability in pulmonary capillaries appeared to be the main cause of the increase in EVLW during whole body hyperthermia.
3) Increase in EVLW during whole body hyperthermia correlated well with both mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). The measurement of mPAP and PVR also assumed the changes in EVLW.
4) Lung edema during whole body hyperthemia was reduced by administration of steroid hormone but not with positive end-expiratory pressure.