1986 Volume 2 Issue 2 Pages 191-197
Using AH100B tumor-bearing rats, effect of local heating by water bath immersion at 41, 43 and 45°C on tissue blood flow was studied in tumor and tumor-adjacent normal muscle. This expermental results showed that 41°C and 43°C local heating caused decrease of tumor blood flow with time dependency. Its reduction could disadvantageously influence the transport of anticancer agents into tumor tissue during lacal hyperthermia. We made another attempt to measure tumor blood flow during experimental hyperthermia combined with Angiotensin II (AGT II), It was recognized that AGT II suppressed decrease of tumor blood flow and led to augment tumor blood flow selectively during hyperthermia. It was thought that hyperhtermochemotherapy combined with AGT II was useful to heighten anticancer effects.
