Development of Efficient and Stereoselective Glycosylation Reactions, Effected by a Functional Group Remote from the Anomeric Center of the Glycosyl Donor

Abstract

The most important consideration for the synthesis of oligosaccharides is the stereocontrol of glycosylation reactions. Recently, we developed new methods for efficient α-sialylation and α-galactosylation by exploiting the effects of a remote substituent on the reactivity and/or stereoselectivity of glycosyl donors. These methods have enabled the efficient synthesis of various natural biologically important glycans.