The One-step Preparation of Sugar Oxazoline Enables the Synthesis of Glycoprotein Having a Definite Structure

Abstract

Sugar oxazoline derivatives are useful donor substrates for N-acetylglucosaminidase-catalyzed glycosylation reactions. In this review, we describe the direct conversion of free sugars to their oxazoline derivatives by using water-soluble dehydrating agents and its application to enzymatic synthesis of complex glycosidic compounds including glycoproteins.