Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
MINIREVIEW (Article for special issue on Galectins)
Synthetic Inhibitors of Galectins: Structures and Syntheses
Vincent DenavitDanny LainéThomas TremblayJacob St-GelaisDenis Giguère
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JOURNALS OPEN ACCESS

2018 Volume 30 Issue 172 Pages SE21-SE40

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Abstract

The recent discovery of the critical involvement of galectins in cancer progression, and in inflammatory and immune responses, has raised this family of β-D-galactoside-binding proteins to the rank of high-priority drug targets by the scientific community. This report will highlight the relevance of glycochemistry toward the efficient development of synthetic galectins inhibitors with high affinity and selectivity, as small molecules or multivalent glycoconjugates.

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© 2018 FCCA (Forum: Carbohydrates Coming of Age)
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