2018 Volume 30 Issue 172 Pages SE97-SE107
The proper function of the immune system entails multiple regulatory pathways aimed at modulating immunogenic and tolerogenic functions of immune cells. Galectins, a family of carbohydrate-binding proteins, control a variety of biological processes involved in activation, differentiation, trafficking and survival of immune cells. In this review we summarize pioneer work and emerging findings highlighting selected functions of galectins as regulatory checkpoints that control innate and adaptive immune cell programs.