Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
MINIREVIEW (Edited by JSCR)
The Functions of O-GlcNAc in Pluripotent Stem Cells
Taichi MiuraShoko Nishihara
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2019 Volume 31 Issue 180 Pages E69-E75

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Abstract

O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a glycosylation characterized by the attachment of a single N-acetylglucosamine (GlcNAc) to the serine/threonine residues of nuclear, mitochondrial, and cytoplasmic proteins. Proteins modified by O-GlcNAc include signaling components, transcription factors, epigenetic regulators, and histones. O-GlcNAc has various functions such as inhibition of phosphorylation, regulation of transcriptional activity, stabilization of proteins, and regulation of intracellular localization. In recent years, O-GlcNAc has been drawing attention as a key factor for regulating the undifferentiated/differentiated state in mouse/human pluripotent stem cells, and the functions of O-GlcNAc have been gradually clarified. In this review, we introduce the versatile functions of O-GlcNAc in mouse/human pluripotent stem cells.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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