Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Unexpected Roles of Exostosin-like 2, EXTL2, in Glycosaminoglycan Biosynthesis and Function
Hiroshi Kitagawa
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2019 Volume 31 Issue 181 Pages SE15-SE17

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Abstract

In 1999, I received the Young Scientist Award from the Japanese Society of Carbohydrate Research for my research leading to the identification of the tumor suppressor EXT-like gene family member EXTL2. Specifically, I identified an N-acetylhexosaminyltransferase that transfers not only N-acetylgalactosamine but also N-acetylglucosamine to the glycosaminoglycan-protein linkage region. Since that award, my laboratory has shown that EXTL2 functions as a suppressor of glycosaminoglycan biosynthesis and that this suppression is enhanced by the xylose kinase FAM20B. Furthermore, we have found that an EXTL2-dependent mechanism that regulates glycosaminoglycan biosynthesis is important for maintaining tissue homeostasis under pathological conditions, and that lack of EXTL2 causes glycosaminoglycan overproduction and structural changes in glycosaminoglycans associated with pathological processes.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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