Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Toward Understanding N-Glycan Functions through Chemical Synthesis
Ichiro Matsuo
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JOURNAL FREE ACCESS

2019 Volume 31 Issue 181 Pages SE38-SE39

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Abstract

N-Glycosylation of secretory and membrane-bound proteins is an essential and highly conserved protein modification of eukaryotes. In the endoplasmic reticulum (ER), a combination of various enzymes, chaperones, lectins and cargo receptors constitutes the “glycoprotein quality control” (GQC) system, which elaborately regulates folding, transport and degradation of glycoproteins. Thus, function of asparagine linked sugar chains in the GQC process has been attracting attention. Understanding of these phenomena has progressed as a result of interaction analyses and substrate specificity studies of glycan related enzymes using synthetic sugar chains. In this review, our approach to the systematic synthesis of the ER type of asparagine linked sugar chains (N-glycans) and recent progress of this field is described.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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