Glycosylation is generally carried out repeatedly as a key reaction while chemically synthesizing oligosaccharides and polysaccharides. Thus, both efficiency and stereoselectivity of the key reaction is important for required quantities of the target product to be highly optimized. Although 1,2-cis glycoside is found in various bioactive glycan structures in both prokaryotes and eukaryotes, a few reports have shown a definite approach to achieving stereoselective formation of these linkages. Our previous developments were used as a key reaction for the synthesis and the further developing of bacterial glycans from Campylobacter jejuni and Mycobacterium tuberculosis, the fragments of the novel antifreeze, xylomannan, isolated from Upis ceramboides, and the post-translationally-modified plant glycoproteins.
