Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Synthetic Study on Glycoconjugates Containing 1,2-cis Glycoside and Their Application
Akihiro Ishiwata
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2019 Volume 31 Issue 181 Pages SE53-SE54

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Abstract

Glycosylation is generally carried out repeatedly as a key reaction while chemically synthesizing oligosaccharides and polysaccharides. Thus, both efficiency and stereoselectivity of the key reaction is important for required quantities of the target product to be highly optimized. Although 1,2-cis glycoside is found in various bioactive glycan structures in both prokaryotes and eukaryotes, a few reports have shown a definite approach to achieving stereoselective formation of these linkages. Our previous developments were used as a key reaction for the synthesis and the further developing of bacterial glycans from Campylobacter jejuni and Mycobacterium tuberculosis, the fragments of the novel antifreeze, xylomannan, isolated from Upis ceramboides, and the post-translationally-modified plant glycoproteins.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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