Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Extracellular O-GlcNAc: From Discovery to Current Developments
Tetsuya Okajima
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2019 Volume 31 Issue 181 Pages SE57-SE58

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Abstract

My group has discovered extracellular O-GlcNAc on the epidermal growth factor repeats of Notch receptors. Unlike OGT-dependent O-GlcNAcylation, extracellular O-GlcNAc occurs in the endoplasmic reticulum by the action of EOGT. Genetic inactivation of eogt in Drosophila revealed that extracellular O-GlcNAc is essential for developmental processes and appears to regulate the function of apical extracellular molecules such as Dumpy. In contrast, extracellular O-GlcNAc is required for the precise control of Notch signaling in mammals. Eogt mutant mice show defects in retinal vascular integrity. Importantly, mutations in EOGT cause Adams-Oliver syndrome, a congenital disorder in humans. These findings indicate diverse but essential biological functions of extracellular O-GlcNAc in Drosophila and mammals. In this article, I will give an overview of the biochemical and biological studies of extracellular O-GlcNAc, summarizing previous findings and current developments.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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