Trends in Glycoscience and Glycotechnology
Online ISSN : 1883-2113
Print ISSN : 0915-7352
ISSN-L : 0915-7352
Article for JSCR 40th Anniversary Issue
Chemical Synthesis of a Highly-Glycosylated Protein: An Example for the Latest Total Chemical Synthesis of O-Glycoproteins
Ryo Okamoto
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2019 Volume 31 Issue 181 Pages SE87-SE88

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Abstract

Recent advances in total chemical synthesis of proteins enable us to prepare complex glycoproteins. Herein, the total chemical synthesis of antifreeze glycoprotein, which is a mucin type O-glycoprotein, is introduced as an example of the latest total chemical synthesis of glycoproteins. The functional analysis of the structurally-defined form of the synthetic O-glycoproteins revealed a unique function of O-GalNAcylation of a protein.

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© 2019 FCCA (Forum: Carbohydrates Coming of Age)
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