Properties of Monoclonal Antibodies Recognizing Chondroitin Sulfate E

Abstract

In in vitro studies, chondroitin sulfate E (CSE) has been found to have various activities, suggesting its importance in the living body. However, the in vitro function of CSE has not been fully elucidated. Antibodies have been used as a tool for assessing the biological roles of sugar chains, but previously reported antibodies react not only with CSE but also with other CS isomers. If an antibody was highly specific and able to detect only CSE, it could be used to study the in vitro activities of CSE or as a probe for detecting diseases marked by abnormal expression or localization of CSE. This paper outlines the properties of antibodies that react with CSE.