Abstract
Embryonic development involves the generation of progenitor cells from proliferating stem cells, followed by migration of progenitor cells to specific sites in tissues and their differentiation into specific cell types. In the nervous system, this stereotypic developmental process proceeds more exquisitely than in any other tissues because of the highly complicated connectivities of neurons required for mature nervous system. Recent studies have revealed that heparan sulfate proteoglycans may play crucial roles in various developmental processes in the nervous system.
