How to Search for a C. elegans Homologue of Your Gene

Abstract

A nematode Caenorhabditis elegans has been used as a model organism for the study of animal development and neurons. Recently, essentially complete DNA sequence of the genome was determined and published [Science (1998), 282, 2011-2045]. C. elegans has become of interest in studying the genes whose biological functions are unknown to biologists who are not studying C. elegans, because not only classic genetics but also reverse genetics such as gene knockout can be used in C. elegans. In this manuscript I will briefly explain the methods of searching for the C. elegans homologue of your interested genes using the Internet. How to use DDBJ has already been described [TIGG (1999), 11, 119-127]. Here I write about the homepages of Washington University Genome Sequencing Center, The Sanger Center and ACeDB.