Systematic Syntheses of Gangliosides

Abstract

The chemistry of the ganglioside synthesis can be divided into three steps: 1) construction of oligosaccharide backbone, 2) introduction of sialic acid into the oligosaccharide backbone, and 3) coupling of the sialo-oligosaccharide and sphingolipid. In this text, the latter two topics are described, first, as the problems common to all gangliosides, and the first topic as the individual problems specific to each subclass of ganglioside.