Abstract
We have developed an efficient synthetic pathway for lipid A and its glycosylation method with Kdo. In combination with several additional new ideas such as the use of an oxidation-resistant benzyl-type protecting group and the application of liquid-liquid partition column chromatography, the synthesis of Re-type lipopolysaccharide has been achieved for the first time. The pathway allows us to synthesize various structural congeners of lipopolysaccharide of high purity, which are necessary to evaluate the biological and physicochemical functions of lipopolysaccharide precisely.
