Abstract
Accumulating evidence shows that the fates of glycoproteins in cells are determined through interactions of their carbohydrate moieties with a variety of intracellular lectins operating as molecular chaperones, cargo receptors, and ubiquitin ligases. Recent advances in developments of high-mannose type oligosaccharide libraries and structural biology of the carbohydrate-lectin interactions have revealed insights into sugar recognition by those intracellular lectins and the underlying mechanisms of quality control of glycoproteins. This article outlines the current knowledge on the molecular basis of sugar recognition by the intracellular lectins that control folding, transport, and degradation of glycoproteins in cells.
