Abstract
Considerable information has been obtained regarding the intermediates and the order of biosynthesis of the glycosaminoglycan portion of proteochondroitin and in its sulfation. Nevertheless, the relationship of these two steps have not been clearly defined. Work in several laboratories, including our own, have indicated a pattern which strongly suggests that sulfation ordinarily takes place together with polymerization in a single Golgi site, and with close interrelationships of sulfation, polymer elongation, and polymer termination. These interactions could contribute to the control of specific variations in location and type of sulfation that might in turn direct specific functions of the proteochondroitin sulfate.
