Abstract
GMP-140, a member of the selectin family of adhesion molecules, is a receptor for neutrophils and monocytes that is expressed on the surface of activated platelets and endothelial cells. The corresponding ligand on leukocytes involves a carbohydrate structure including the CD15 antigen, lacto-N-fucopentaose III. GMP-140 mediated cell binding is likely critical in the hemostatic and inflammatory response to tissue and vascular injury. In addition these interactions may be important in pathologic processes such as atherosclerosis or metastasis. Future investigations will further elucidate structure-function relationships of GMP-140 and its ligand as well as the cellular consequences of adhesion. This data will lead to the design of in vivo studies to determine the biologic significance of these interactions.
