1994 Volume 6 Issue 27 Pages 17-28
In recent years β1-6-N-acetylglucosaminyltransferase activities have been described in numerous mammalian tissues and cell types. From these studies it is clear that alterations in the expression level of these enzymes and their corresponding carbohydrate structures on the cell surface are associated with development, differentiation and oncogenesis. However, the molecular basis for these changes as well as their functional significance remain at present unknown. Recent advances in the molecular cloning and expression of β1, 6-N-acetylglucosaminyltransferase cDNAs will provide exciting new approaches to study their differential expression patterns at the molecular level and to correlate the expression of the corresponding carbohydrates with functionS.
