Abstract
The glycosyltransferase-mediated synthesis of oligosaccharide analogs is reviewed, with emphasis on the use of modified sugar-nucleotide donors or modified acceptors as substrates. A survey of the most studied enzymes: β(1→4)-galactosyltransferase, N-Acetylglucosaminyltransferase I, α(1→3/4)-fucosyltransferases and α(2→3 or 2→6)-sialyltransferases, shows them to be very useful for the rapid production of chemically modified di-, tri- and tetrasaccharide analogs.
