Tropical Medicine and Health
Online ISSN : 1349-4147
Print ISSN : 1348-8945
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T-cell Responses to Dengue Virus in Humans
Ichiro KuraneTakaji MatsutaniRyuji SuzukiTomohiko TakasakiSiripen KalayanaroojSharone GreenAlan L. RothmanFrancis A. Ennis
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2011 Volume 39 Issue 4SUPPLEMENT Pages S45-S51

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Abstract

Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. These highly activated T cells are DENV-specific and oligoclonal. Multiple kinds of lymphokines are produced by the activated T cells, and it has been hypothesized that these lymphokines are responsible for induction of plasma leakage, one of the most characteristic features of DHF. Thus, T-cells play important roles in the pathogenesis of DHF and in the recovery from DENV infection.

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© 2011 by The Japanese Society of Tropical Medicine
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