STUDIES ON THE PYROGEN (VII)

Potentiation of Pyrogenic Activity on the Some Pyrogens by Venom

Abstract

1) The pyrogenicity and acute toxicity of three venoms (Agkistrodon halys blomhoffii, Trimeresurus flavoviridis and Trimeresurus okinavensis) were studied; the pyrogenicities for rabbits were corresponding to the toxicities for mice.
2) The pyrogenicities of vonoms for rabbits were not so stronger than the pyrogen of E. coli, and they showed monophasic body temperature curves.
3) Venoms potentiated the activity of the pyrogen of E. coli and influenza virus.
4) These results were discussed with some additional experiments.