Japanese Journal of Tropical Medicine and Hygiene
Online ISSN : 2186-1811
Print ISSN : 0304-2146
ISSN-L : 0304-2146
IMMUNOBLOT ANALYSIS OF ANTIBODY RESPONSE BEFORE AND AFTER TREATMENT OF HUMAN STRONGYLOIDIASIS
SHUICHI SHIMABUKUROYOSHIYA SATOJUN KOBAYASHIISAO SHIMABUKUROYOSHIYUKI SHIROMA
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1993 年 21 巻 3 号 p. 149-155

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抄録
Qualitative analysis of antibody response before and 12 months after treatment of human strongyloidiasis was performed to identify the antigenic component which may be useful for serological evaluation of the effectiveness of postchemotherapy. The immunoblotting patterns changed significantly after successful treatment in almost all patients; some responses decreased in their intensity and some disappeared. Whereas, the patterns of reactivity after treatment could not be distinguished from those before treatment in patients who were interpreted to be equivocal for complete cure because their antibody levels did not show a significant decrease after treatment. The immunoblotting patterns, however, varied considerably for each patient and it was difficult to identify the antigenic component which may be effective to detect reduced antibody responses early after treatment.
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© Japanese Society of Tropical Medicine
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