Japanese Journal of Tropical Medicine and Hygiene
Online ISSN : 2186-1811
Print ISSN : 0304-2146
ISSN-L : 0304-2146
ASSOCIATION OF DENGUE VIRUS TYPE-SPECIFIC IGG ON PLATELETS IS SPECIFIC FOR THE ACUTE PHASE IN AN IMPORTED JAPANESE PATIENT WITH SECONDARY DENGUE 2 VIRUS INFECTION
KAZUNORI OISHISHINGO INOUETSUYOSHI KURAMOTOSHOZABURO ONIZUKAMARIKO SAITOFUTOSHI HASEBEKOUICHI MORITATSUYOSHI NAGATAKE
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2003 年 31 巻 4 号 p. 223-225

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The mechanism of thrombocytopenia in dengue virus infection remains unknown. We report herein an imported case of a 21-year-old male Japanese with dengue fever caused by secondary dengue 2 virus infection. The thrombocytopenia detected around the day of defervescence was associated with an increased level of platelet-associated IgG (PAIgG). The eluate from the platelets during the acute phase of this case contained an increased activity of anti-dengue virus 2 IgG, while the eluate from platelets during the convalescent phase contained a low level of anti-dengue 2 IgG. These findings suggest the transient formation of PAIgG involving anti-dengue 2 virus IgG during the acute phase of secondary dengue 2 virus infection.

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© Japanese Society of Tropical Medicine
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