抄録
A 34-year-old female patient visited Nagasaki City Hospital because of increasing headache and diplopia on the 29th of November 1974. Clinical diagnosis of intracranial tumor was made on physical examinations and she was admitted to Nagasaki University Hospital for surgical operation of the tumor. At the craniotomy, multiple spherical, grey to dark brown nodules were seen scattered in the brain tissues (Fig. 1) and histological examination revealed numerous brown fungal spores and hyphae in necrotic area surrounded by granulomatous reaction and Phialophora pedrosoi were isolated by culture using Sabouraud's agar slants (Figs. 2 and 3). The patient was treated with oral administration of 5-Fluorocytosine with temporary improvement and she died of bronchopneumonia on the 7th of June 1975. On autopsy, multiple fungus granulomata were seen in the brain and also in the kidney but there were no skin or mucous membrane lesions. In Japan, 10 cases of cerebral chromomycosis have been reported up to 1975, and they are summarized in the table and discussed.
