抄録
We have prepared new type biocompatible, water-soluble phospholipid polymer composed of phosphorylcholine units and phenyl boronic acid units. This polymer could make polymer hydrogel multilayer combined with polyvinyl alcohol (PVA). By using photo-reactive PVA and silanized titanium, durable chemical bonding between titanium and the polymer hydrogel was achieved by UV-irradiation. The final material of multilayered polymer hydrogel on titanium was constructed by utilizing the layer-by-layer method through ester complex of boronic acid and dial. Furthermore, the release study of anticancer agent paclitaxel dissolved in a certain interlayer of polymer hydrogel was performed. As the surfaces had changed from bare to modified titanium, the contact angles have changed depending on the surface properties. According to changing surfaces, the characteristic signals of X-ray photoelectron spectroscopy were also observed. And the contact angles reproducibly have alternated as the outermost layer is changed from PVA to PMBV60. As the locations of PTX layer in the polymer hydrogel multilayer changed, the releasing profile toward the time of PTX could be controlled.
