Transactions of the Materials Research Society of Japan
Online ISSN : 2188-1650
Print ISSN : 1382-3469
ISSN-L : 1382-3469
Development of cell/transistor interface for real-time and noninvasive monitoring of potassium ion release based on apoptosis using biologically-coupled field effect transistor
Taiichiro MurakamiToshiya SakataAkira MatsumotoMadoka TakaiKazuhiko IshiharaYuji Miyahara
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2010 年 35 巻 2 号 p. 255-258

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  We report the real-time and noninvasive detection of K+ release through cell membrane using a biologically-coupled field effect transistor (bio-FET). To achieve this purpose, the cell/transistor interface, which can selectively detect K+ release through the ion-channel, was developed. The K+ release through the ion-channel caused by apoptosis (programmed cell death) could be electrically detected using the bio-FET with crown ether monolayer. Thus we have demonstrated the ability to analyze selectively the ion channel behavior using the bio-FET modified with the functional monolayer.
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© 2010 The Materials Research Society of Japan
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