Synthesis of a Macro-initiator Based on Poly(trimethylene carbonate) and Its Functionalization toward Living Radical Polymerization

抄録

This study reports new functionalized material for biomaterial. The polymeric micelles were studied by many researchers for addition of function. Therefore, we designed a block polymer to have hydrophilic and hydrophobic segments by hybrid polymerization. It would be expected the capacity to respond to stimulus voluntarily and autonomously.
  Hybrid polymerization was performed by a combination of ring opening polymerization of TMC and living radical polymerization of two types of multifunctional vinyl monomers, namely, N-isopropylacrylamide (NIPAAm) and 2-methacryloyloxyethyl phosphorylcholine (MPC). Copolymerization with NIPAAm and MPC from the macro-initiator using poly(trimethylene carbonate) was successfully achieved. The resulting polymer was characterized by structural analysis of ¹H-NMR, GPC, and IR. In addition it spontaneously formed self-aggregation in water. This hybrid polymerization approach is capable of producing polymer micelles with versatile hydrophilic segment.