2012 年 37 巻 1 号 p. 89-94
We previously reported the bioavailability enhancement of lipophilic Coenzyme Q10 (CoQ10) by complexing with γ-Cyclodextrin (γCD) in spite of poorly-soluble characteristics in water. We recently found the most plausible explanation mechanism which is due to the significant increase of water solubility of CoQ10 with the aid of sodium taurocholate (Na TCA) as a major component of bile acid in small intestine. By adding Na TCA into a water suspension of CoQ10-γCD complex, water soluble Na TCA-γCD complex is formed by the substitution of guest molecule from CoQ10 to Na TCA since Na TCA has higher association constant with γCD than CoQ10. Generally CoQ10 molecule agglutinates in water to form visible particles. But the dissociated CoQ10 from γCD cavity could be significantly solubilized in water captured in the midst of Na TCA micelle. This method could be applied for the other nutra-ceuticals like Curcumin and R-α-Lipoic acid. In the wake of the breakthrough projects using various nutra-ceutical-γCD complexes and Na TCA, we could also establish this new nanotech formulation system in personal care field by the combination of cosme-ceutical-γCD complexes with a cosmetic ingredient, dipotassium glycyrrhizate (GZK2) which has high association constant as well as Na TCA.
