Abstract
The influence of HMG-CoA reductase inhibitors (statins) on glucose metabolism is controversial. Additionally, the effects of statins on the glycemic control in Japanese type 2 diabetic patients have not been fully evaluated. Thus, we evaluated the effect of 2.5 mg daily rosuvastatin (Rs) and 10 mg daily atorvastatin (At) treatment on the glucose metabolism by examining the HbA1c, glycated albumin (GA), and several parameters obtained from the 75 g OGTT. A cross-over trial (each treatment lasted three months) was performed in non-obese Japanese type 2 diabetic patients. While the fasting plasma glucose (FPG), HbA1c and GA levels after the three-month treatment with Rs were not significantly different from baseline, the GA, but not the FPG and HbA1c, was significantly increased by At treatment. However, there were no significant differences in the FPG, HbA1c or GA between the Rs and At treatments. The areas under the curve for glucose and insulin, HOMA-R and the whole body insulin sensitivity index, the insulinogenic index, and disposition index as a marker of β-cell function after three months of Rs or At treatment did not differ from those at baseline, and there were no significant differences between the two treatments. Therefore, 2.5 mg daily Rs treatment may not affect the glucose metabolism in Japanese non-obese type 2 diabetic patients.
