Abstract
We examined the effects of exenatide on the glycemic control and eating behavior in obese Japanese type 2 diabetic patients. During the 12-week study, we administered exenatide (5 μg, twice/day) to 22 outpatients and increased the dose up to 10 μg twice/day in cases where a sufficient effect for weight reduction or improvement of the glycemic control could not be achieved. Before and after the follow-up period, we measured the HbA1c (NGSP), fasting plasma glucose and serum CPR levels, and evaluated the patients' eating behavior based on a questionnaire with seven separate domains. After the exenatide administration, the HbA1c improved and the plasma CPR level was significantly increased, and the body weight (BW) was significantly decreased. The eating behavior of the patients was significantly improved in all of the domains. When we compared the effects of the HbA1c improvement and BW reduction after exenatide administration in the subanalyses in accordance with the improvement or non-improvement of the HbA1c, the reduction or non-reduction of the BW, and male or female gender, we could not find any correlations between the effects on the improvement of the HbA1c and BW reduction. In obese female patients, the effects of exenatide on the eating behavior, HbA1c improvement and, BW reduction were the most advantageous.
