Abstract
A 48-year-old male presented with a rapid exacerbation of diabetes mellitus and elevated serum levels of hepatobiliary enzymes. Although he had a history of mild diabetes mellitus, he had not ever been pointed out to have liver dysfunction. He had elevated serum levels of IgG4, and autoimmune pancreatitis with sclerosing cholangitis was diagnosed by ultrasonography, computed tomography and endoscopic retrograde cholangiopancreatography. In addition, he had elevated serum titers of anti-GAD antibody and his diabetes mellitus was diagnosed to be slowly progressive type 1 diabetes mellitus. Steroid therapy and insulin therapy were administered for the autoimmune pancreatitis and type 1 diabetes mellitus, respectively. After steroid therapy, the patient's serum levels of hepatobiliary enzymes and IgG4 were normalized, and the swelling of the pancreas disappeared. Although type 1 diabetes mellitus and autoimmune pancreatitis are both autoimmune diseases whose target organ is the pancreas, there have been few case reports in which both diseases developed in the same patient. Further case reports are required.
