Diagnostic Criteria for Slowly Progressive Type 1 Diabetes Mellitus (Slowly Progressive Insulin-Dependent Diabetes Mellitus) - A Report by the Committee on Type 1 Diabetes, Japan Diabetes Society -

Abstract

The diagnostic criteria for slowly progressive type 1 diabetes mellitus (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the "Committee on Type 1 Diabetes" of the Japan Diabetes Society. The following three criteria are all required for a definitive diagnosis of SPIDDM: 1) the presence of islet-associated autoantibody at some time point during the disease course; 2) the absence of ketosis or ketoacidosis at the diagnosis of diabetes and no need for insulin treatment to correct hyperglycemia immediately after the diagnosis principally; and 3) a gradual decrease in insulin secretion over time, with insulin treatment required more than 3 months after the diagnosis of diabetes, and the exhaustion of endogenous insulin secretion (fasting serum C-peptide < 0.6 ng/mL) at the last observed time point. Should a patient meet only criteria 1 and 2 but not 3, they should be diagnosed with "slowly progressive type 1 diabetes mellitus (probable)" because of their non-insulin-dependent diabetic state.