Abstract
Conflicting results on the effect of sulfonylureas upon glucagon secretion of the pancreas prompted us to investigate the changes in glucagon levels in the pancreatic vein after the infusion of Gliquidone (ARDF-26) in dogs.
ARDF-26 (4 mg) was constantly infused into the pancreatic artery in four anesthetized dogs with or without a previous administration of tolbutamide (200 mg) 40 minutes in advance, and changes in the levels of insulin and glucagon in the pancreatic vein were measured. Blood glucose in the femoral artery did not change after the administration of sulfonylureas. The insulin levels in the pancreatic vein rose sharply after the infusion of the sulfonylureas and returned to the initial level despite the duration of the administration of the drugs. Glucagon levels in the pancreatic vein fell after the start of the infusion of the drugs. The decrease in glucagon level in the pancreatic vein was more prominent following ARDF-26 infusion compared with tolbutamide.
It is concluded that ARDF-26 as well as tolbutamide could suppress glucagon secretion from the pancreas in dogs.
