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Volume 16, Issue 3
Displaying 1-9 of 9 articles from this issue
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(1) Effects of Ipsilateral Tenotomy of the Gastrocnemius MuscleYutaka Aoki, Yuko Shimoda, Kikuyo Shimoda, Tastuo Shirai, Masateru Toy ...1973 Volume 16 Issue 3 Pages 197-202
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThese studies were designed to analyze the factors which induced compensatory hypertrophy of muscle in normal and alloxan diabetic rats and to compare the differences between the mechanism of hypertrophy and insulin action. Compensatory hypertrophy was induced in the rat plantaris and soleus muscles on one limb by ipsilateral tenotomy of the synergistic muscle, the gastrocnemius.
Experimental results were as follows;
1) In normal rats, the wet weight of gastrocnemius of the operated limb was 18.5% smaller and that of the plantaris and soleus was 17% and 24% greater, respectively, than their controls after 7 days of operation.
The gain of the dry weight of these hypertrophied muscles was directly proportional to that of the wet weight. Inspite of the gain of weight, the water content of hypertrophied muscles was about 80% of the wet weight.
In alloxan diabetic rats, the rate and extent of muscle hypertrophy of the plantaris and soleus were almost similar to that of normal rats.
Moreover, work induced hypertrophy of skeletal muscle occurred independently of developmental growth and insulin action.
2) The accumulation of α-aminoisobutyric acid-14C (α-AIB-14C) by the gastrocnemius, plantaris and soleus of normal rats was studied in vivo after ispilateral tenotomy of the gastrocnemius. Simultaneously, the extra-cellular space of each muscle was determined as inulin-3H space.
The hypertrophied muscles, the plantaris and soleus of operated limb, significantly concentrated α-AIB-14C than the contralateral controls within 3 to 5 days after operation.
On the other hand, the atrophied muscle, the gastrocnemius, concentrated α-AIB-14C to lesser extent than the contralateral control, but statistically insignificant.
The extra-cellular space of operated gastrocnemius did not diminish and that of ipsilateral plantaris and soleus increased in its volume at 3 to 5 days after the tenotomy of gastrocnemius.View full abstractDownload PDF (972K) -
Mitsuru Hoshi, Michitoshi Inoue, Motoaki Shichiri, Nobuyoshi Oji, Yuki ...1973 Volume 16 Issue 3 Pages 203-207
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSLocal application of insulin for infected burn wound of diabetic patients is not yet prevailing so far. The authors have tentatively treated a 36 year old diabetic woman with neuropathy and thrombophlebitis in both lower extremities by local application of lente insulin direct to the burn infected wound. After several days of application of gauze soaked in lente insulin solution diluted with saline by 1: 10, the burn infected wound showed apparent clearing tendency and aggravation of wound healing. The authors noted the improvement not only in the local wound healing, but also in the systemic control of diabetes mellitus judged from urine and blood sugar levels and have discussed the local application of insulin to be an expectable treatment to the persistent infected wound of diabetic patients.View full abstractDownload PDF (3842K) -
Kazuo Katsumata, Masako Hagihara1973 Volume 16 Issue 3 Pages 208-212
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe effect of six hypoglycemic sulphonylureas upon the oxidative phosphorylation of the isolated rat liver mitochondria was examined and following results were obtained.
1. All of drugs tested, i. e, tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide and glyclopyramide were found to be uncouplers.
2. They were also found to decrease respiratory release of 20μM DNP.
3. They could induce latent ATPase activity of intact rat liver mitochondria. ATPase activity induced by these drugs were reduced to zero by the addition of rutamycin just like the DNP.
These experimental results were discussed in relation to the side effects and hypoglycemic actions of these drugs.View full abstractDownload PDF (760K) -
Kempei Matsuoka1973 Volume 16 Issue 3 Pages 213-225
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNeurological examinations of diabetes mellitus are important either for early diagnosis or for preventive measures of urinary tract infections, intractable renal damage, leg lesions and so on.
Quantitative examinations of vibratory sense (by 128 Hz vibrometer), motor nerve conduction velosity (MCV), pupillary reactions (by cinepupillogram) and residual urine volume (by post voiding film) were studied in 286 diabetics, 51 borderline cases and 137 control subjects, being compared to the history and clinical features of diabetes mellitus. Absent ankle jerks, prolonged MCV and prolonged latency period of the pupillary reaction are correlative to the diabetic control. The incidence of prolonged MCV, spastic miosis and sluggish reaction of the pupils and abnormal residual volume of the urine is remarkably higher in diabetics than borderline cases, and increases with progression of retinopathy and with the duration of diabetes.
Absent ankle jerks and impaired vibratory sense and sluggish reaction of the pupils are the earliest signs for diabetes mellitus. Abnormal pupillary reaction including spastic miosis and abnormal post voiding films are not only found in diabetics with long duration but also common in younger group aged below 29 years old, and visceral neuropathy is often an initial sign of diabetes.
Insulinogenic index was measured in 92 cases with mild glucose intolerance. The cases with 30'ΔI/ΔG of 0.49 or less were not always compulsory to have diabetic neuropathy, but most of the cases who had any single sign of neuropathy showed low 30'ΔI/ΔG.
In general, the impaired vibratory sense, absent ankle jerks and slow contraction of the pupils are found in early stage with relatively higher incidence and spastic miosis, sluggish and shallow reaction of the pupils, abnormal post voiding film and prolonged MCV are closely related to diabetic retinopathy and also to the degree of control. Therefore, the development of diabetic neuropathy is caused by metabolic derangement but its progress appears to be related to morphological disorder such as diabetic microangiopathy.View full abstractDownload PDF (1973K) -
Akira Ohneda, Hiroshi Itabashi, Ken Horigome, Kiyoshi Matsuda, Munehik ...1973 Volume 16 Issue 3 Pages 226-230
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSConflicting results on the effect of sulfonylureas upon glucagon secretion of the pancreas prompted us to investigate the changes in glucagon levels in the pancreatic vein after the infusion of Gliquidone (ARDF-26) in dogs.
ARDF-26 (4 mg) was constantly infused into the pancreatic artery in four anesthetized dogs with or without a previous administration of tolbutamide (200 mg) 40 minutes in advance, and changes in the levels of insulin and glucagon in the pancreatic vein were measured. Blood glucose in the femoral artery did not change after the administration of sulfonylureas. The insulin levels in the pancreatic vein rose sharply after the infusion of the sulfonylureas and returned to the initial level despite the duration of the administration of the drugs. Glucagon levels in the pancreatic vein fell after the start of the infusion of the drugs. The decrease in glucagon level in the pancreatic vein was more prominent following ARDF-26 infusion compared with tolbutamide.
It is concluded that ARDF-26 as well as tolbutamide could suppress glucagon secretion from the pancreas in dogs.View full abstractDownload PDF (546K) -
Nobuyoshi Oji, Mitsuru Hoshi, Noboru Araki, Akira Okada, Yukio Shigeta ...1973 Volume 16 Issue 3 Pages 231-234
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe cluster analysis was applied to asses the genesis of microangiopathy of the small blood vessels of nailbed in diabetics. The score of patients were calculated by the points given to abnormal findings in loops of nailbed vessels as reported previously.
Abnormal findings of the small blood vessels in nailbed such as dilatations, wavings, tortuosities, branchings, nodular apical enlargements (NAE), tanglings, granularities and so called the fine capillaries were found to be composed of three groups. The first cluster includes granularities and fine capillaries and the composition seems to indicate a narrowing of small blood vessels (sclerotic changes). The second one consists of dilatation and NAE findings, and seems to express the changes due to dilatation of the vessels. The third one includes remaining four findings and the composition may indicate the changes in a vessel length.
The results of this cluster analysis suggests the findings in small blood vessels of nailbed in adultonset diabetics to be composed at least three different kinds of pathological changes.View full abstractDownload PDF (672K) -
Atsushi Hiratsuka, Kazuo Ishiwata, Nobusada Kuzuya1973 Volume 16 Issue 3 Pages 235-241
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA fifty-two years old male, had had diabetes mellitus for four years, had maintained good control with 0.5 g of chlorpropamide daily, and had had no retinopathy, nephropathy, or neuropathy. Before admission he erroneously took 1.0 g of chlorpropamide daily for fourteen days. On the fifteenth day he became hypoglycemic, with drowsiness and abnormal behavior. On the sixteenth day, he was admitted to our hospital.
The results of our clinical investigation may be summarized as follows:
1) The lowering of the serum chlorpropamide concentration in this case was more prompt than in the other cases reported.
2) Low blood glucose levels (33-43 mg/dl) and high serum IRI levels (83-86μU/ml) were observed for several hours after admission. When the blood sugar levels increased to 122mg/dl from the initial low level of below 77 mg/dl, the serum IRI levels decreased to 53μU/ml from the initial high level of over 80μU/ml. Higher levels of fasting serum IRI were observed after he had recovered from the hypoglycemia while hospitalized.
3) Although higher serum HGH levels were observed on the first day of admission, all of the values obtained while he was hospitalized were within normal limits.
4) On the first day of hospitalization, the serum 11-OHCS levels were higher and showed abnormal diurnal variation, but on the subsequent days, after the patient's recovery from the hypoglycemia, normal diurnal variations recurred.
5) The serum thyroxin levels were low on the first day of hospitalization, and then returned to normal little by little. In contrast to this, the serum resin-sponge uptakes of T3-1311 were within normal limits throughout the hospital stay. These results coincided with the hypothesis, that chlorpropamide inhibits the binding of the thyroxin to thyroxinbinding globulin.
6) Markedly low levels of serum total cholesterol were observed in the first three days of hospitalization. We have found no reports pointing out the hypocholesterolemia during hypoglycemia which our results showed to be noticeable.View full abstractDownload PDF (1059K) -
1973 Volume 16 Issue 3 Pages 253-269
Published: May 31, 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3016K) -
1973 Volume 16 Issue 3 Pages 273
Published: 1973
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (40K)
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