Abstract
Blood sugar, plasma immunoreactive insulin (IRI) and erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity were determined in 25 nontreated patients with glycosuria during an oral glucose tolerance test. The erythrocyte G-6-PD activity seemed to be lower in the group with a diabetic pattern of blood sugar response than in the group with a normal pattern in the glucose tolerance test. However, statistically a difference of the G-6-PD activity between two groups, normal and diabetic, was not significant. A low erythrocyte G-6-PD activity was shown in the group with low plasma IRI response and/or low Δplasma IRI/Δplood sugar ratio after oral administration of 50g glucose. Any correlation between fasting blood sugar levels and fasting erythrocyte G-6-PD activity was not shown statistically and a correlation coefficient “r” was 0.0951 (p>0.05, N=25). On the other hand, a positive correlation between fasting erythrocyte G-6-PD activity and each of plasma IRI levels at 30 minutes after oral glucose load and of Δplasma IRI/Δplood sugar ratio was observed and an individual correlation coefficient “r” was 0.4431 (p<0.05, N=25) and 0.5496 (p<0.01, N=23), respectively.
