Serum Lipid Level in Japanese Diabetics
I. Relationship between Serum Lipid Level and Vascular Complications
1974 Volume 17 Issue 5 Pages 402-411
Details
1974 Volume 17 Issue 5 Pages 402-411
A statistical analysis was made in studying the serum lipid level of Japanese diabetics and its relations to diabetic vascular complications. Those studied were 715 diabetics, 1, 095 borderline cases and 573 normal subjects seen in the Center for Adult Diseases, Osaka.
Hypercholesteremia was found at a higher rate among the subjects in the diabetic group, especially among females, than in the borderline or normal groups. Hypertriglyceridemia was also found more frequently in diabetic cases, especially in males.
Hypercholesteremia was closely associated with obesity in both sexes, but it was as frequent in non-obese females as in obese males. The incidence of hypercholesteremia was somewhat higher in cases with ischemic findings on ECG, but it had no relation to hypertension or arteriosclerotic changes in the occular fundus.
There were marked correlations between hypertriglyceridemia and obesity, but not between hypertriglyceridemia and the existence of vascular complications. Cholesterol and triglycerides levels were not closely correlated with a suggestion that each lipid might work independently.
A partial correlation analysis revealed that the cholesterol level was related to sex and obesity, and the triglyceride level was related to obesity. But no significant correlation was found between cholesterol and ECG score (CHD).
Analysis of an principal components indicated that vascular complications were closely related to hypertension, and that both cholesterol and triglycerides had a marked relationship to obesity, although they were different in nature. The results of the principal component analysis also suggested that ECG scores might be divided into two different characteristics; one due to hypertensive changes that were dominant in this series, and the other due to atherosclerotic changes related to cholesterol.
It was concluded that vascular complications in Japanese diabetics were related more to hypertensive changes than to cholesterol or triglycerides.
