Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Volume 17, Issue 5
Displaying 1-13 of 13 articles from this issue
  • Harry Keen
    1974 Volume 17 Issue 5 Pages 397-400
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Download PDF (783K)
  • I. Relationship between Serum Lipid Level and Vascular Complications
    Akira Sasaki, Naruto Horiuchi, Tsugio Kitamura, Fumiko Nakagawa, Hisaa ...
    1974 Volume 17 Issue 5 Pages 402-411
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A statistical analysis was made in studying the serum lipid level of Japanese diabetics and its relations to diabetic vascular complications. Those studied were 715 diabetics, 1, 095 borderline cases and 573 normal subjects seen in the Center for Adult Diseases, Osaka.
    Hypercholesteremia was found at a higher rate among the subjects in the diabetic group, especially among females, than in the borderline or normal groups. Hypertriglyceridemia was also found more frequently in diabetic cases, especially in males.
    Hypercholesteremia was closely associated with obesity in both sexes, but it was as frequent in non-obese females as in obese males. The incidence of hypercholesteremia was somewhat higher in cases with ischemic findings on ECG, but it had no relation to hypertension or arteriosclerotic changes in the occular fundus.
    There were marked correlations between hypertriglyceridemia and obesity, but not between hypertriglyceridemia and the existence of vascular complications. Cholesterol and triglycerides levels were not closely correlated with a suggestion that each lipid might work independently.
    A partial correlation analysis revealed that the cholesterol level was related to sex and obesity, and the triglyceride level was related to obesity. But no significant correlation was found between cholesterol and ECG score (CHD).
    Analysis of an principal components indicated that vascular complications were closely related to hypertension, and that both cholesterol and triglycerides had a marked relationship to obesity, although they were different in nature. The results of the principal component analysis also suggested that ECG scores might be divided into two different characteristics; one due to hypertensive changes that were dominant in this series, and the other due to atherosclerotic changes related to cholesterol.
    It was concluded that vascular complications in Japanese diabetics were related more to hypertensive changes than to cholesterol or triglycerides.
    Download PDF (1720K)
  • II. Comparative Study between Urban and Rural Area
    Akira Sasaki, Naruto Horiuchi, Takaichiro Suzuki, Hisaaki Inui
    1974 Volume 17 Issue 5 Pages 412-419
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    It is well known that serum lipid levels vary depending upon regional conditions, such as different dietary habits or certain environmental factors. The present study was conducted to find possible factors influencing regional differences in the relation between serum lipid levels and diabetic vascular complications.
    The subjects studied were 237 inhabitants of No-se Town, a rural mountainous agricultural area located about 40km North of Osaka City. They were given GTT at a diabetes mass survey and were given a follow-up examination 7 years later. The 2, 383 subjects who were dealt with in the preceeding report were used as controls. These latter were mostly inhabitants of the urban area of Osaka and its adjacent cities.
    For both sexes the serum cholesterol level was higher in the urban subjects than in the rural subjects. It was higher in females than in males in both urban and rural subjects.
    Although the serum triglycerides level, was higher in urban males than rural males, rural females revealed a higher level than urban females. For both regional groups, diabetics had a clearly higher incidence of hypertriglyceridemia.
    The correlation between cholesterol and triglyceride levels, which was significant in the urban series, was not significant for the rural series. This suggests a different pattern of distribution of the two lipids.
    The incidence of hypertension was higher in the rural subjects but that of coronary heart disease was higher in the urban subjects. Thus it can be concluded that, though there is a clear relationship between cholesterol and coronary heart disease, triglycerides play little part in the development of coronary heart disease, because hypertriglyceridemia was more frequent in rural females.
    It was also observed that the cholesterol level in No-se significantly increased over the past seven years, because of the change in socioeconomical conditions.
    A partial correlation analysis indicated that the cholesterol level was related to FBS, and that the triglyceride level was related to obesity and FBS, but not to ECG scores (CHD). In an analysis of principal components, the variables were classified into three groups ; The first related to glucose metabolism, the second to hypertensive changes, and the third to the lipid metabolism. ECG scores were closely related to hypertensive changes but not to cholesterol or to triglycerides.
    As a conclusion, the lipid metabolism in diabetics was primarily attributable to a geographical factor, being modified by glucose metabolism as a secondary factor. No significant effect of hyperlipemia on diabetic vascular complications was found.
    Download PDF (1307K)
  • Mitsuo Inada, Yoshio Kazama, Schunichiro Kurata, Kanji Kasagi, Hideo T ...
    1974 Volume 17 Issue 5 Pages 420-426
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    In 129 patients with diabetes mellitus (64 obese patients and 65 non-obese patients), measurements were made befcrc treatment was begun of blood sugar concentrations as well as the immuno-reactive insulin (IRI) concentrations in plasma before and 30, 60, 90, 120, 180 and 240 minutes after oral loading of 50g glucose. The patterns of IRI response to oral glucose loading were divided into two types based upon the values of the sum of IRI concentrations before and after the loading the delayed response with ΣIRI over 101 and the low response with ΣIRI under 100.
    All of the patients were treated in the out-patient clinic of Tenri Hospital for over 6 months, and the effects of diabetic treatment were investigated in relation to body weight, level of fasting blood sugar, and the IRI response measured before the treatment. The results revealed a close relation between the effects of the treatment and these three factors. Moreover, in order to obtain a plan for the selection of diabetic treatment, the relation between the mode of treatment (diet, sulfonyl urea, and insulin) and the three above-mentioned factors was investigated in 80 patients who were in good control.
    19 of 25 obese patients, whose fasting blood sugar was under 180mg/dl and who had shown a delayed IRI response, were in good control with the diet treatment alone. Five of 12 obese patients, whose fasting blood sugar was over 180mg/dl and who had shown a delayed IRI response, also were in good control with only the dietetic therapy, but 7 patients required treatment with sulfonyl urea. In non-obese patients with fasting blood sugar under 180mg/dl, 13 of 17 patients with a delayed IRI response were in good control with the dietetic therapy alone, while 5 of 8 patients with the low IRI response required the sulfonyl urea treatment. 15 of 16 nonobese patients with fasting blood sugar over 180 mg/dl required sulfonyl urea or insulin theraz py, regardless of the pattern of IRI response.
    Thus, the following plan of diabetic treatment was made out and it was thought to be clinically useful as a guide to the treatment of diabetic patients.
    Fasting blood sugar
    IRI response.
    Treatment.
    Obese patient under 180mg/dl Delayed Diet
    Obese patient over 180mg/dl Delayed Diet or Sulfonyl urea
    Non-obese patient under 180mg/dl Delayed Diet
    Non-obese patient under 180mg/dl Low Diet and Sulfonyl urea
    Non-obese patient over 180mg/dl Delayed Diet and Sulfonyl urea or Insulin
    Non-obese patient over 180mg/dl Low Diet and Sulfonyl urea or Insulin
    Download PDF (1255K)
  • Takayoshi Kobayashi
    1974 Volume 17 Issue 5 Pages 427-432
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Liver changes were observed in KK-strain mice from an age of 1 day to 20 months.
    1. Fatty degeneration: Biphasic changes were observed in the liver of KK mice. In an early phase, the hepatic cells were filled with uniform fine fatty droplets and the cytoplasms showed a foamy appearance. This occurred for a short period from 1 day to 3 weeks after birth, and gradually decreased in number of fatty droplets, and returned to normal by 4 weeks after birth. In a later stage, at an age of over 4 months, irregular fatty droplet infiltration of the centrolobular hepatic cells was nearly always accompanied by an elevation of the blood sugar level. After the age 10 months, the blood sugar level descended to an almost normal level. This latter fatty degeneration, however, was noted continuously.
    2. Nodular changes (hepatocellular adenoma): The hepatic cells showed irregular sizes after the age of one or two months. In over 4 month-old mice, nodular hyperplasia was observed. These changes were noted in all animals at the age of over 17 months. Microscopically the nodule showed a picture equivalent to that of hepatocellular adenoma.
    Download PDF (8477K)
  • Hiroshi Suzuki
    1974 Volume 17 Issue 5 Pages 433-441
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Although it has been known in general that abnormal glucose tolerance is observed in hyperthyroidism, there have been few reports on the change of plasma insulin and blood glucose by arginine infusion. In our present study performed by giving arginine to patients with hyperthyroidism and hypothyroidism, an inverse correlation was observed between the change of plasma insulin and glucose levels and the thyroid functions. The thyroid function was represented by serum thyroxine levels (T4), resin sponge uptake of triiodothyronine (RSU), basal metabolic rate (BMR) and thyroidal 131I uptake (131I uptake). Arginine hydrochloride (0.5g/kg of body weight) dissolved in 200ml of physiological saline was administered by intravenous infusion from a cubital vein over 30 minutes to the patients with hyperthyroidism and hypothyroidism and to the normal controls fasting since early in the morning. Blood samples were taken before and 15, 30, 45, 60, 90 and 120 minutes after the start of the infusion. Plasma insulin was determined by the double antibody adioimmunoassay and the blood glucose was determined by autoanalyzer. Plasma insulin in normal individuals reached to its peak 30 minutes after the arginine infusion (ΔIRI=32.5±3.0μU/ml). The JIRI at 30 minutes in hyperthyroid patients was as low as (2.6±2.6μU/ml), whereas a considerably high JIM at 30 minutes (87.6+19. 9μU/ml) was observed in hypothyroid patients. A statistically significant inverse correlationship (p<0.01) was observed between ΔIRI at 15, 30, 45 and 60 minutes and the thyroid functions. This correlation was most marked at 15 minutes, and became less marked as time lapsed. Blood glucose levels in normal individuals showed a biphasic curve which reached its peak at 30 minutes and its nadir at 60 minutes. A flat blood glucose curve was obtained for hyperthyroidism, and a mcnophasic curve was observed with an extremely high peak for hypothyroidismus. A statistically significant inverse correlation was observed between the thyroid functions and the ΔBS at 15 and 30 minutes, although it was less marked than in the case of ΔIRI.
    Download PDF (1447K)
  • Manabu Sakuta, Shin-ichi Kimata, Eishi Miki, Kinori Kosaka
    1974 Volume 17 Issue 5 Pages 442-449
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    A case of bullosis diabeticorum is reported with a review of the literature.
    A 45 year old Japanese male with onset of diabetes at age 33 and a history of poor control with insulin thereafter was admitted because of furunclosis.
    Following admission and after establishment of fair control, two large bullae appeared succes sively 47 days apart without obvious cause on his left and right legs respectively. Histologically, the former was subepidermal bulla which caused ulceration and healed 2 months later with a scar. Although the latter was not biopsied, this lesion was believed to be a intraepidermal bulla because the lesion healed in 2 weeks without forming any scar. Light microscopy showed a thickening of smaller vessels in the cutis and electron microscopy of the gastrocnemius muscle revealed a marked thickening of the capillary basement membrane.
    In view of these and other data, together with a review of the literature, it is suggested that this condition is related, among the various skin disorders related to vascular complications of diabetes, to diabetic microvascular lesions.
    Download PDF (4946K)
  • Soji Okada, Koichi Kawanishi, Tadashi Ofuji
    1974 Volume 17 Issue 5 Pages 451-452
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Five male guinea pigs were immunized by subcutaneous injections of bovine crystalline insulin emulsified in Freund's complete adjuvant. The guinea pig anti-bovine insulin sera (GPABIS) were kept at-20°C until used.
    The experiment was carried out by using the multiple well double diffusion technique. Phosphate buffer saline (0.05M, pH 7.2) was used for the preparation of a 1.0% agar gel.
    GPABIS produced a precipitin line with porcine as well as with bovine insulin. Monocomponent pork insulin also produced a precipitin line. The bovine and porcines precipitin lines were fused completely with the monocomponent precipitin line.
    It was demonstrated that GPABIS contained precipitating insulin antibodies and produced precipitation with monocomponent insulin.
    Download PDF (1564K)
  • Hiroshi Kaji, Hajime Ide, Tadahiro Aikawa, Makoto Murao
    1974 Volume 17 Issue 5 Pages 453-456
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    In metabolic disorders, such as diabetic ketoacidosis, it is well known that a characteristic breath order is one of the distinct symptoms of patients. In view of this we have engaged in the quantitative analysis of acetone concentrations in the expired alveolar air (alv-Ac) using the gas chromatographic method. Venous blood β-hydroxybutyrate (B-βHB) was also determined using the enzymatic method. In the normal subjects, the fasting level of alv-Ac was 0.9+0.3, μg/L (n=39) and B-βHB was 0.06±0.07mM (n=33). In the diabetic patients, the levels of both alv-Ac (2.37±2.40, μg/L) and B-βHB (0.283±0.204mM) (n=9) were higher than in the normal subjects. Thus, a correlation was shown (r=0.9626). A subject with diabetes mellitus accompanied with hyperthyroidism has also been described in whose case an improvement of the fasting level of alv-Ac and B-βHB parallel with an improvement in the level of blood sugar was observed during his period under treatment with insulin and an antithyroid drug.
    In patients with hyperthyroidism, the level of alv-Ac was unexpectedly high (2.96±2.71μg/ L) (n=8), especially in two cases: 7.2 and 6.9, μg/L, respectively.
    Hereafter, changes in blood and urinary ketone bodies should be reevaluated in comparison with alv-Ac levels under various conditions.
    Download PDF (580K)
  • [in Japanese]
    1974 Volume 17 Issue 5 Pages 457-462
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Download PDF (2356K)
  • [in Japanese]
    1974 Volume 17 Issue 5 Pages 463-466
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Download PDF (3599K)
  • [in Japanese]
    1974 Volume 17 Issue 5 Pages 467-472
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Download PDF (1010K)
  • [in Japanese]
    1974 Volume 17 Issue 5 Pages 473-476
    Published: September 30, 1974
    Released on J-STAGE: August 10, 2011
    JOURNAL FREE ACCESS
    Download PDF (7552K)
feedback
Top