Abstract
Effects of administration of clofibrate upon heparin-induced lipoprotein lipase activity were studied in diabetic patients with endogenous hypertriglyceridemia.
Clofibrate administration, (1500mg, daily) for 15-20days, induced a significant increase in the lipoprotein lipase activity and a significant reduction of the plasma triglyceride level. A single administration of the drug (590mg) did not affect the lipoprotein lipase activity despite the elevation of plasma clofibrate level similar to the elevation during the periodic administration. There was no significant correlation between the increase in the lipoprotein lipase activity and the decrease in plasma triglyceride following the periodic clofibrate administration.
Thus, clofibrate seems to influence indirectly the heparin-induced lipoprotein lipase activity.
