Abstract
Lipoprotein patterns of normal people and hyperlipidemic patients with glucose intolerance were determined by Nobel's agarose gel electrophoretic method using slight modifications.
Changes in the lipoprotein patterns were also studied during the patients' treatment with insulin, sulfonylurea or diet only.
The pre-beta-lipoprotein band was frequently detected not only in the sera of the patients but also in the sera of normal younger people (75 %) and normal older persons (88 %). The average pre-beta lipoprotein in total lipids was 12.8 % in younger persons and 14.2% in older persons by the densitometric method. All patients treated regained normal fasting blood sugar levels. In 7 insulin treated patients, who had severe glucose intolerances, the serum lipid levels and lipoprotein patterns returned to normal but in 9 patients treated with diet alone or with diet and sulfonylurea, the serum lipid and the lipoprotein pattern remained abnormal. The results suggested that hyperlipidemia with severe glucose intolerance is due chiefly to insulin deficiency but that hyperlipidemia with a slight or moderate glucose intolerance is also related to other facters such as hereditary facters in patients with primary hyperlipidemia.
