Abstract
The authors have previously reported that the incorporation of 14C-glucose into aortic triglyceride was decreased in rats with streptozotocin-induced diabetes, and have suggested the possibility of a decrease in the synthesis of aortic triglycerides in these rats. In this study, they measured the aortic tri-, di- and monoglyceride content, as well as the activities of aortic lipase and monoglyceride hydrolase in rats. Aortic lipase was measured by the method of Hayase et al. using 3H-glyceryl trioleate as a substrate and the aortic monoglyceride hydrolase was determined by the method of Noma et al. using 3H-glyceryl monooleate. When diabetic rats were compared with control rats, no significant differences were found between the two groups in either the aortic monoglyceride content or the lipase activity. However there was a significant decrease in the tri- and diglyceride aortic content as well as in the monoglyceride hydrolase activity in the diabetic rats.
It was concluded that the decrease in the aortic triglyceride content of the diabetic rats was due not to the increase in the breakdown, but rather, possibly due to the decrease in the synthesis of triglyceride.
