Abstract
The relationships between change in body weight before the beginning of treatment, degree of metabolic disorder, and effect of dietary treatment were investigated in newly diagnosed noninsulin dependent diabetics. The following results were obtained. (1) Based on the extent of weight loss during a period of 3 months before the beginning of treatment, 90 diabetics were grouped as follows. Group I (N=33, 36.7%) showed no significant loss of weight;Group II (N=40, 44.4%) showed a loss of weight of less than 3 kg per month; and Group III (N=17, 18.9%) showed a loss of weight of more than 3 kg per month. (2) The mean fasting blood sugar (FBS) levels at the beginning of treatment in these three groups were 168.1±41.6 mg/dl (Group I), 230.8 ±60.8mg/dl (Group II) and300.4+49.9mg/dl (Group III).The hemoglobin AIC (HbAIc) levels were 5.2±1.3%(Group I), 7.5±1.9%(Group II) and 9.1±2.1%(Group III). The ΣIRI/ΣBS values during 509 O-GTT were 0.19±0.17 (Group I), 0.09±0.07 (Group II).and 0.02±0.01 (Group III).Among the three groups, the differences in mean values of FBS, HbAIc and ΣIRI/ΣBS were statistically significant, respectively. (3) Dietary treatment was effective for all cases in Group I, irrespective of the values of FBS, HbAic and E, ΣIRI/ΣBS at the beginning of treatment, but was not effective in some cases of Group II (30.0%) and Group III (64.7%) whose FBS levels were similar to those in cases of Group I.In Group II, the mean FBS (278.8±61.9 mg/dl) and HbAic (9.3±0.9%) in noneffective cases were higher than in effective cases (210.3±48.2 mg/dl and 6.5±1.6%). In Group III, the HbArc in noneffective cases (9.5±1.5%) was significantly higher than in effective cases (7.8±0.4%).Futhermore, in Groups II and III, dietary treatment was less effective in non-obese diabetics at the beginning of treatment.
These findings suggest that changes in body weight before the beginning of treatmenC, may serve as a good indicator of the therapeutic outcome of dietary treatment in patients with NIDDM.
