Clinical Implications of Islet Cell Surface Antibodies (ICSA) in Non-Insulin Dependent Diabetes Mellitus

In Relation to Pancreatic B Cell Function and HLA Antigens

Abstract

The overall prevalence of ICSA was 14.8%(21/142) in NIDDM and 21.3%(16/75) in IDDM. There were no significant differences in the overall prevalence of microsomal antibodies, sex, body mass index or age at onset between ICSA-positive and ICSA-negative NIDDM. Nine out of the 21 ICSA-positive NIDDM became insulin-dependent 1-3 years later. The urinary C-peptide/creatinine (U-CPR/U-Cr) level (mean±SE) in ICSA-positive NIDDM (44.0±5.5μg/g; n=20) was significantly (p<0.05) lower than that in ICSA-negtive NIDDM (64.1±4.3μg/g; n=48). The U-CPR/U-Cr level in ICSA-positive NIDDM decreased significantly (p<0.05) 1-3 years later. High frequencies of HLA-B7 and-DRw 9 were observed in ICSA-positive NIDDM.
Thus, in some NIDDM, pancreatic B cell function gradually deteriorated in relation to ICSA and certain HLA types.