Abstract
The contents and molecular sizes of glucagon-like peptide-1 immunoreactivity (GLP-1 IR), glucagon. immunoreactivity (GI), and glucagon-like immunoreactivity (GLI) in rat tissues were studied by radioimmunoassay.
Although GLP-1 IR, GI, and GL1 were all found in the highest concentrations in the pancreas, GLP-1 IR and GLI were also widely distributed throughout the intestinal tracts. In the pancreas, GLP-1 IR mainly consisted of a large molecular form of immunoreactivity (MW ca. 13, 500) and GLP-1 (1-37). In contrast, only a small molecular form of GLP-1 (7-37 or 7-36 amide) was found in the jejunum, ileum, and colon.
