Abstract
The plasma concentrations of 1, 5-anhydro-D-glucitol (1, 5-AG) were determined in normal subjects, and in patients with renal glucosuria and with diabetes mellitus (9-18 years old), as diagnosed by oral glucose tolerance test.
No sex-or age-related differences in the concentrations of plasma 1, 5-AG were noted in normal subjects. The plasma 1, 5-AG level in patients with diabetes mellitus with marked glycosuria was significantly lower than that in normal subjects. Moreover, significant reduction of plasma 1, 5-AG was also found in patients with renal glycosuria without glucose intolerance.
Significant negative correlation was also observed between fasting plasma 1, 5-AG and Σ urinary glucose excretion during the oral glucose tolerance test.
These results suggest that the reduction of plasma 1, 5-AG concentration may be caused by the increased excretion of urinary glucose, due to concomitant excretion of 1, 5-AG in urine.
