1989 Volume 32 Issue 1 Pages 27-33
The present study was undertapen to investigate the feeding behavior of the streptozotocin (STZ)-induced diabetic rat by employing special apparatus at Gunma University. Experiment 1: Studies in chronic diabetes
1) Ambulation was decreased in the dark, but not in the light in diabetic rats.
2) Diabetic rats drank an average of 278 ml in 24 hours, 6 times more than the control group.
3) food intake in diabetic rats was more than twice that the control rats.
Experiment 2: Studies on the acute effect of STZ.
1) Three days after STZ administration, a significant decrease in ambulation was observed in the diabetic rats.
2) Within 3 hours after STZ administration, an initial increase in drinking was observed. We have demonstrated that there are a variety of abnormal behaviors in STZ-induced diabetic rats including ambulation, drinking and food intake behavior. Further studies are needed to determine when these abnormalities are normalized by insulin administration.
