Abstract
We report a study of serial plasma IAPP levels in an obese NIDDM patient associated with diabetic ketoacidosis. The patient was an obese 20-year-old male.On September 13, 1989, he was admitted to our hospital because of diabetic ketoacidosis.On admission, urine CPR was 25.7μg/day, and plasma CPR and TAPP responses to glucagon injection were low. The patient was treated with continuous subcutaneous insulin injection (CSII).Three months later, urine CPR was 64.2μg/day, and after gradually reducing the insulin dose, he was finally treated with diet alone under good glycemic control.Plasma IAPP response to glucagon became normal along with recovery of C-peptide secretion.This, resulst clearly suggest that plasma IAPP response reflects pancreatic B-cell function in NIDDM patients and could be used another index of B-cell function.
