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Volume 34, Issue 6
Displaying 1-11 of 11 articles from this issue
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Reiko Kawahara1991 Volume 34 Issue 6 Pages 485-489
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (647K) -
Teruo Shima, Yutaka Yano, Atsushi Esaki, Hitoshi Ura, Yasuhiro Sumida, ...1991 Volume 34 Issue 6 Pages 491-497
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSEleven patients with diabetes mellitus (Male/Female: 2/9, IDDM/NIDDM: 5/6) complicated by Basedow's disease were found among 440 patients with DM (IDDM/NIDDM: 46/394) and 270 patients with Basedow's disease.
Statistical analysis showed the mean HbA1c of 5 IDDM patients with Basedow's disease to be significantly lower than in the control subjects.With regard to diabetic complications, while 5 IDDM patients with Basedow's disease had no proteinuria, no significant differences were observed in the incidence of retinopathy or neuropathy.
A family history of DM was present in 5 of the 11 cases and of thyroid disease in 3.Analysis of the HLA antigens of these 11 patients revealed HLA DR-4 in all 5 IDDM patients with Basedow's disease and in 4 of the 6 NIDDM patients with Basedow's disease.
These findings indicate that both genetic factors and autoimmune mechanisms play importantroles in relation to complication of IDDM by Basedow's disease, and while genetic factors arebelieved to play a role, the role of autoimmune mechanisms in complication of NIDDM by Basedow'sdisease is undeniable.View full abstractDownload PDF (814K) -
Shuichi Takagi, Hideharu Kakita, Yoshinobu Tsutsumi, Manabu Sawada, Go ...1991 Volume 34 Issue 6 Pages 499-505
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn order to investigate the pathogenesis of incipient diabetic nephropathy, the effect of an angiotensin converting enzyme inhibitor (ACEI) on urinary albumin excretion ratio (AER), glomerular filtration rate (GFR) and blood pressure (BP) was investigated in rats with streptozocin (SZ)-induced diabetes.
We employed the following three groups: 1) SZ-treated (60 mg/BW ? kg) rats the (SZ group: n=8), 2) SZ-treated with Captopril (50 mg/BW·kg/day) as the ACEI (CPT group: n=8), 3) non-diabetic controls (C group: n=8).
GFR, AER and BP were measured from one week to 8 or 12 weeks after the onset of diabetes (blood glucose> 350 mg/d/) in each of the groups.In the SZ group, AER was significantly higher throughout the experiment than in the C group (p<0.05-0.001) and GFR, based on inulin clearance, also increased significantly from one to 4 weeks after the onset of diabetes (p<0.05-0.01).On the other hand, these increments in AER and GFR were significantly reduced in the CPT group in comparison with the SZ group (AER: p<0.05-0.01, GFR p<0.05-0.02).BP was also significantly reduced in the CPT goup when compared with the C group (p< 0.05-0.01).
These findings suggest that the increase in urinary albumin excretion (UAE) in SZ diabetic rats may be caused by hyperfiltration and that ACEI was able to reduce UAE by improving hyperfiltration.View full abstractDownload PDF (1161K) -
Toeko Matsumoto, Naoki Ishizuka, Chikuma Hamada, Hidenori Amano, Yasuo ...1991 Volume 34 Issue 6 Pages 507-514
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe clinical data of 2400 outpatients who made visits to the Third Department of Internal Medicine, Tokyo University Hospital for more than one year between 1957 and 1985 were analyzed to identify the characteristics and etiology of angiopathies in non-insulin dependent diabetics.1) Entry data were composed of 73 clinical items.The total amount of follow-up data represented 15, 722 person-years.2) More than 90% of the basic data were documented.More than 90% of the data for each year were, noted with respect to FBG, blood pressure, body weight, retinopathy, proteinuria and ischemic ECG.More than 70% of the data was recorded with respect to total cholesterol, creatinine and triglyceride since 1961, 1975 and 1978, respectively.More than 30% of the data was obtained with respect to IRI on GTT since 1973.3) 2150 patients (male 1207, female 943) were diagnosed as diabetics according to the criteria of the Japan Diabetes Society (1982).The characteristics of 67 IDDM patients and 2083 NIDDM patients differed with respect to gender ratio, age at onset, degree of obesity and hyperglycemia.The prevalence of juvenile-onset NIDDM was found to be higher at our institution than in western countries.The entry data for our study are summarized in this report, since they will be used as the basis for further analyses of risk factors for the development of diabetic angiopathies.View full abstractDownload PDF (1372K) -
N. Fukase, H. Takahashi, H. Manaka, M. Tominaga, H. Sasaki1991 Volume 34 Issue 6 Pages 515-521
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSTo investigate the mechanism of oral fat-stimulated secretion of the two most potent incretin candidates, gastric inhibitory polypeptide (GIP) and truncated glucagon-like peptide-1 (tGLP-1), we studied changes in these peptides after fat ingestion using long-chain triglyceride (LCT) or medium chain triglyceride (MCT) in man.25g LCT was given orally to nine healthy volunteers and 25g MCT was given orally to six healthy volunteers.After LCT ingestion plasma levels of GIP peaked at 60 min and glucagon-like immunoreactivity (GLI) at 30 min, and both remained high up to 120 min, whereas plasma glucose, insulin and glucagon levels were unchanged.Plasma levels of GLP-1 NT, measured with antiserum R1043 (N-terminus directed), increased markedly.Estimated values of tGLP-1, obtained by the subtraction of GLP-1 NT values from those of GLP-1 CT, increased markedly within 30 min and declined rapidly within 60 min.However, after MCT ingestion, plasma levels of all of the above parameters remained unchanged.Plasma levels of triglyceride and chylomicron were increased by LCT ingestion, but only plasma very low density lipoproteins were increased by MCT ingestion.The results suggest that the absorption process, especially chylomicron formation, is an important determinant of fat stimulated tGLP-1 release, as in GIP release.View full abstractDownload PDF (1096K) -
Hiroyuki Odaka, Yasuo Sugiyama, Hitoshi Ikeda1991 Volume 34 Issue 6 Pages 523-530
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe antidiabetic activity of pioglitazone was evaluated in spontaneously diabetic GK rats given a sucrose solution.In the rats given a 30% sucrose solution in addition to the stock diet and water, insulin resistance in the liver became more pronuonced and plasma glucose, insulin and triglyceride levels increased markedly as compared with those in the control rats given the stock diet and water alone.Furthermore, long-term sucrose solution-drinking aggravated the congenital defects in GK rats, such as glucose intolerance and dull insulin response to glucose, and decreased the pancreatic insulin content to 50% of that in the controls.Diabetic complications were also aggravated by drinking the sucrose solution: urinary albumin excretion increased, and motor nerve conduction velocity was delayed.When pioglitazone (3.2 mg/kg/day) was administered to the rats given the sucrose solution starting from the second week, the severity of the above mentioned diabetic states, which deteriorated in response to the sucrose drinking, was markedly reduced.The congenital defects in glucose metabolism and pancreatic function in GK rats were however not normalized. These findings suggest that pioglitazone can improve glucose and lipid metabolism by reducing insulin resistance in the liver.View full abstractDownload PDF (2813K) -
Risa Narahara, Koji Nakano, Motoharu Kondo, Takahiro Kanatsuna1991 Volume 34 Issue 6 Pages 531-536
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 27-year-old man, who was diagnosed as having diabetes mellitus at 21 years of age in 1981, was started on insulin therapy in 1985.
He was admitted to our department in March 1987 because of his poor glycemic control. IDDM was diagnosed from the laboratory data.His glycemic control gradually improved with appropriate insulin injections, but suddenly hypoglycemia occurred. Even after the cessation of the insulin injections, however, hypoglycemia persisted.So we questioned him and he admitted that he had been injecting high doses of insulin after binge eating. The diagnosis of Bulimia nervosa with IDDM was made according to established criteria.
After psychotherapy the intentional high dose insulin injections and binge eating stopped.His blood sugar level was then well controlled.
This report is a rare case of IDDM associated with Bulimia nervosa, one of the eating disorders. This case could suggest that psychological factors are important in diabetic controlView full abstractDownload PDF (835K) -
Masateru Matuoka, Yasuo Goto, Kiyoshi Inagaki, Yoshimi Hayabe, Tamotu ...1991 Volume 34 Issue 6 Pages 537-542
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 58-year-old man visited our hospital with complaints of high grade fever and tenderness of the genitalia. He had received no treatment despite the fact that glycosuria had been detected one year previously. The patient had no apparent history of genital trauma or infection. His swollen and painful scrotum developed into a well demarcated and gangrenous lesion. After admission, a great deal of pus drained from the lesion and debridement of scrotal skin was performed combined with insulin administration and the wound was closed. The patient's diabetes mellitus was well controlled and his general condition improved.View full abstractDownload PDF (3471K) -
Tomohiro Mitsukawa, Hirotaka Toshimori, Masamitsu Nakazato, Jiro Takem ...1991 Volume 34 Issue 6 Pages 543-548
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a study of serial plasma IAPP levels in an obese NIDDM patient associated with diabetic ketoacidosis. The patient was an obese 20-year-old male.On September 13, 1989, he was admitted to our hospital because of diabetic ketoacidosis.On admission, urine CPR was 25.7μg/day, and plasma CPR and TAPP responses to glucagon injection were low. The patient was treated with continuous subcutaneous insulin injection (CSII).Three months later, urine CPR was 64.2μg/day, and after gradually reducing the insulin dose, he was finally treated with diet alone under good glycemic control.Plasma IAPP response to glucagon became normal along with recovery of C-peptide secretion.This, resulst clearly suggest that plasma IAPP response reflects pancreatic B-cell function in NIDDM patients and could be used another index of B-cell function.View full abstractDownload PDF (907K) -
Masahiko Terada, Hitoshi Yasuda, Takashi Hisanaga, Tohru Kawabata, Ken ...1991 Volume 34 Issue 6 Pages 549-552
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSingle-fiber electromyography (SFEMG) of anterior tibial muscle was performed in 23 type 2 diabetic subjects to determine its usefulness in evaluating diabetic neuropathy (DN).Jitter (MCD) and fiber density (FD), which are believed to indicate axonal degeneration with reinnervation, were measured in all patients Both parameters were significantly higher in patients with DN than in those without DN MCD: 77.9 ± 17.2 μ s vs 57.0 ± 16.6 μ s (p<0.01), FD: 2.74 ± 1.06 vs 1.68 ± 0.31 (p<0.05). All patients with DN showed abnormal values (mean+2SD of the values of healthy subjects) for either of MCD or FD, whereas none of the patients who showed normal values for both parameters had neuropathy, On the other hand, 6 of 13 patients without DN showed an abnormality in one of the other parameter.
These results suggest that SFEMG might be a sensitive method to detect DN and useful to electrophysiologically evaluate the pathological process of DN.View full abstractDownload PDF (548K) -
1991 Volume 34 Issue 6 Pages 553-561
Published: June 30, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (2192K)
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